Project mode
Hours times your rate is the labor. Add a revision buffer, add the costs that are specific to this job, then your margin. The last line — your effective hourly rate if the job runs 30% over — is the one to look at before you accept a fixed price.
Product mode
Enter the price you're thinking of and the fees the platform takes. What's left is what you keep per sale. Divide the hours you'll spend making it (at your rate) by that figure and you get the number of sales just to earn back your own time. For most moms making printables, that number is the moment of clarity.
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If you don't have a rate yet, get one from the Hourly Rate Calculator first.